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Offenbacher S, Barros S, Mendoza L, Mauriello S, Preisser J, Moss K, de Jager M, Aspiras M. Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans. J Clin Periodontol 2010; 37: 324–333. doi: 10.1111/j.1600‐051X.2010.01543.x

Aim: The goal of this study is to characterize the changes in 33 biomarkers within the gingival crevicular fluid during the 3‐week induction and 4‐week resolution of stent‐induced, biofilm overgrowth mediated, experimental gingivitis in humans.

Methods: Experimental gingivitis was induced in 25 subjects for 21 days followed by treatment with a sonic powered toothbrush for 28 days. Clinical indices and gingival crevicular fluids were collected weekly during induction and biweekly during resolution. Samples were analysed using a bead‐based multiplexing analysis for the simultaneous …