作者
Yize Li, Eduard Porta-Pardo, Collin Tokheim, Matthew H Bailey, Tomer M Yaron, Vasileios Stathias, Yifat Geffen, Kathleen J Imbach, Song Cao, Shankara Anand, Yo Akiyama, Wenke Liu, Matthew A Wyczalkowski, Yizhe Song, Erik P Storrs, Michael C Wendl, Wubing Zhang, Mustafa Sibai, Victoria Ruiz-Serra, Wen-Wei Liang, Nadezhda V Terekhanova, Fernanda Martins Rodrigues, Karl R Clauser, David I Heiman, Qing Zhang, Francois Aguet, Anna P Calinawan, Saravana M Dhanasekaran, Chet Birger, Shankha Satpathy, Daniel Cui Zhou, Liang-Bo Wang, Jessika Baral, Jared L Johnson, Emily M Huntsman, Pietro Pugliese, Antonio Colaprico, Antonio Iavarone, Milan G Chheda, Christopher J Ricketts, David Fenyö, Samuel H Payne, Henry Rodriguez, Ana I Robles, Michael A Gillette, Chandan Kumar-Sinha, Alexander J Lazar, Lewis C Cantley, Gad Getz, Li Ding, Eunkyung An, Meenakshi Anurag, Jasmin Bavarva, Michael J Birrer, Anna Calinawan, Michele Ceccarelli, Daniel W Chan, Arul M Chinnaiyan, Hanbyul Cho, Shrabanti Chowdhury, Marcin P Cieslik, Felipe da Veiga Leprevost, Corbin Day, Marcin J Domagalski, Yongchao Dou, Brian J Druker, Nathan Edwards, Matthew J Ellis, Myvizhi Esai Selvan, Steven M Foltz, Alicia Francis, Tania J Gonzalez Robles, Sara JC Gosline, Zeynep H Gümüş, Tara Hiltke, Runyu Hong, Galen Hostetter, Yingwei Hu, Chen Huang, Emily Huntsman, Eric J Jaehnig, Scott D Jewel, Jiayi Ji, Wen Jiang, Lizabeth Katsnelson, Karen A Ketchum, Iga Kolodziejczak, Jonathan T Lei, Yuxing Liao, Caleb M Lindgren, Tao Liu, Weiping Ma, Wilson McKerrow, Alexey I Nesvizhskii, Chelsea Newton, Robert Oldroyd, Gilbert S Omenn, Amanda G Paulovich, Francesca Petralia, Boris Reva, Karin D Rodland, Kelly V Ruggles, Dmitry Rykunov, Sara R Savage, Eric E Schadt, Michael Schnaubelt, Tobias Schraink, Zhiao Shi, Richard D Smith, Xiaoyu Song, Jimin Tan, Ratna R Thangudu, Nicole Tignor, Joshua M Wang, Pei Wang, Ying Cindy Wang, Bo Wen, Maciej Wiznerowicz, Xinpei Yi, Bing Zhang, Hui Zhang, Xu Zhang, Zhen Zhang
发表日期
2023/8/31
期刊
Cell
卷号
186
期号
18
页码范围
3921-3944. e25
出版商
Elsevier
简介
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer drivers by identifying their significant cis-effects and distal trans-effects quantified at the RNA, protein, and phosphoprotein levels. Salient observations include the association of point mutations and copy-number alterations with the rewiring of protein interaction networks, and notably, most cancer genes converge toward similar molecular states denoted by sequence-based kinase activity profiles. A correlation between predicted neoantigen burden and measured T cell infiltration suggests potential vulnerabilities for immunotherapies. Patterns of cancer hallmarks vary by polygenic protein abundance ranging from uniform to heterogeneous. Overall, our work demonstrates the …
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Y Li, E Porta-Pardo, C Tokheim, MH Bailey, TM Yaron… - Cell, 2023