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The Psychiatric Genomics Consortium has published the largest GWAS of bipolar disorder (BD) (41,917 cases and 371,549 controls) which identified 64 BD risk loci. However, each locus encompasses many associated genetic variants and genes, and those causal for BD remain largely unknown. Fine-mapping is a rapid, scalable and cost-effective approach to computationally prioritize likely causal genes and SNPs for functional laboratory experiments.

We fine-mapped the 64 BD risk loci identified by the largest BD GWAS to date, as published by the Psychiatric Genomics Consortium (PGC3). Stepwise conditional analysis of each locus using GCTA-COJO and the Haplotype Reference Consortium (HRC) LD reference panel, indicated one association signal per locus. To allow exploratory analysis, we selected two different numbers of maximum causal variants per each locus (–max-num-causal =1 and –max-num …