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Ataxia-Telangiectasia Mutated (ATM) is a serine-threonine kinase that activates checkpoint signaling, leading to dsDNA breaks (DSBs), cell death, and acts as a DNA damage sensor. ATMs belong to a large family of phosphatidylinositol 3-kinase (PIKKs) that are involved in cell growth and division. Ataxia-telangiectasia is a rare human disease characterized by cerebellar deterioration, excessive cellular sensitivity toward dissemination, and a disposition to carcinoma caused by a mutation in the ATM gene. A rapid increase in the kinase activity at the time of double-strand break was observed and considered an attractive drug target. Structurally, ATM consists of a proline-rich region and a leucine zipper, which helps in the DNA binding. This protein shows a significant starring role in the steady growth and the immune and nervous system activities. Here, we aimed to provide a comprehensive knowledge of different …