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The susceptibility of Helicobacter pylori to methanol extracts of 12 Iranian medicinal plants used in folk medicine for the treatment of gastric ailments including peptic ulcers disease was screened against one metronidazole-sensitive and one-metronidazole resistant strain of H. pylori using the disk diffusion method. Active extracts (zone of inhibition ≥15 mm) were then re-assayed to obtain the minimum inhibitory concentration (MIC) against 12 clinical isolates of H. pylori by using the agar dilution method. Extracts of the aerial part of Artemisia dracunculus L. (Compositae) and Teucrium polium L. (Lamiaceae), leaves of Salvia mirzayanii Rech. & Esfand. (Lamiaceae) and Salvia officinalis L. (Lamiaceae), flowers of Zataria multiflora Boiss. (Lamiaceae), fruits of Bunium persicum (Boiss.) B. Fedtsch. (Apiaceae), Carum carvi L. (Apiaceae), Heracleum persicum Desf. ex Fischer (Apiaceae), Pimpinella anisum L. (Apiaceae …