作者
Joseph L McClay, Andrey A Shabalin, Mikhail G Dozmorov, Daniel E Adkins, Gaurav Kumar, Srilaxmi Nerella, Shaunna L Clark, Sarah E Bergen, Swedish Schizophrenia Consortium, Christina M Hultman, Patrik KE Magnusson, Patrick F Sullivan, Karolina A Aberg, Edwin JCG van den Oord
发表日期
2015/12
期刊
Genome biology
卷号
16
页码范围
1-16
出版商
BioMed Central
简介
Background
Genetic influence on DNA methylation is potentially an important mechanism affecting individual differences in humans. We use next-generation sequencing to assay blood DNA methylation at approximately 4.5 million loci, each comprising 2.9 CpGs on average, in 697 normal subjects. Methylation measures at each locus are tested for association with approximately 4.5 million single nucleotide polymorphisms (SNPs) to exhaustively screen for methylation quantitative trait loci (meQTLs).
Results
Using stringent false discovery rate control, 15 % of methylation sites show genetic influence. Most meQTLs are local, where the associated SNP and methylation site are in close genomic proximity. Distant meQTLs and those spanning different chromosomes are less common. Most local meQTLs encompass common SNPs that alter CpG sites (CpG …
学术搜索中的文章
JL McClay, AA Shabalin, MG Dozmorov, DE Adkins… - Genome biology, 2015