作者
Jan A Staessen, Tim Nawrot, Elly Den Hond, Lutgarde Thijs, Robert Fagard, Karel Hoppenbrouwers, Gudrun Koppen, Vera Nelen, Greet Schoeters, Dirk Vanderschueren, Etienne Van Hecke, Luc Verschaeve, Robert Vlietinck, Harry A Roels
发表日期
2001/5/26
期刊
The Lancet
卷号
357
期号
9269
页码范围
1660-1669
出版商
Elsevier
简介
Background
Human exposure to chemicals is normally monitored by measurement of environmental pollutants in external media. We investigated whether biomarkers in adolescents can show exposure to, and health effects of, common environmental pollutants.
Methods
We recruited 200 17-year-old adolescents (120 girls) from a rural control area and from two suburbs polluted by a lead smelter and two waste incinerators. We measured biomarkers of exposure and of effect in blood and urine samples, and obtained questionnaire data. School doctors measured testicular volume and staged sexual maturation.
Findings
Internal exposure was mostly within current standards. Concentrations of lead and cadmium in blood, PCBs (polychlorinated biphenyls) and dioxin-like compounds in serum samples, and metabolites of VOCs (volatile organic compounds) in urine were higher in one or both suburbs than in the control …
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JA Staessen, T Nawrot, E Den Hond, L Thijs, R Fagard… - The Lancet, 2001