查看文章

Both interferon γ (IFN-γ) produced by T helper 1 (T_H1) lymphocytes and interleukin-4 (IL-4) produced by T_H2 lymphocytes were reduced in either bulk circulating mononuclear cells or mitogen-induced CD4⁺ T cell clones from the peripheral blood of individuals infected with human immunodeficiency virus (HIV). There was a preferential reduction in clones producing IL-4 and IL-5 in the advanced phases of infection. However, enhanced proportions of CD4⁺ T cell clones producing both T_H1-type and T_H2-type cytokines (T_H0 clones) were generated from either skin-infiltrating T cells that had been activated in vivo or peripheral blood T cells stimulated by antigen in vitro when cells were isolated from HIV-infected individuals. All T_H2 and most T_H0 clones supported viral replication, although viral replication was not detected in any of the T_H1 clones infected in vitro with HIV. These results suggest that HIV (i) does not …