作者
Marie-Pierre Piccinni, Maria-Grazia Giudizi, Roberta Biagiotti, Lucio Beloni, Loretta Giannarini, Salvatore Sampognaro, Paola Parronchi, Roberto Manetti, Francesco Annunziato, Claudia Livi
发表日期
1995/7/1
期刊
Journal of immunology (Baltimore, Md.: 1950)
卷号
155
期号
1
页码范围
128-133
简介
The effect of progesterone (P) on the cytokine production profile of Ag-specific human CD4+ T cell lines and clones was investigated. T cell lines specific for purified protein derivative or streptokinase (SK) derived in the presence of P exhibited significant increased ability to produce IL-5 in comparison with T cell lines derived in the absence of P. Moreover, IL-4 was significantly increased in SK-specific T cell lines derived in the presence of P in comparison with SK-specific T cell lines derived in the absence of this hormone. In addition, SK-specific T cell lines generated in the presence of P developed into T cell clones showing a Th0-, instead of Th1-like, cytokine profile. Furthermore, SK-specific T cell clones with an established Th1 profile of cytokine secretion did express mRNA for, and produced detectable amounts of, IL-4 when stimulated with P in combination with insoluble anti-CD3 mAb. Combined …
引用总数
学术搜索中的文章
MP Piccinni, MG Giudizi, R Biagiotti, L Beloni… - Journal of immunology (Baltimore, Md.: 1950), 1995