作者
Maurizio Zazzi, Rolf Kaiser, Anders Sönnerborg, Daniel Struck, Andre Altmann, Mattia Prosperi, Michal Rosen‐Zvi, A Petroczi, Yardena Peres, Eugen Schülter, CA Boucher, F Brun‐Vezinet, PR Harrigan, L Morris, M Obermeier, C‐F Perno, P Phanuphak, Deenan Pillay, RW Shafer, A‐M Vandamme, Kristel van Laethem, AMJ Wensing, Thomas Lengauer, Francesca Incardona
发表日期
2011/4
期刊
HIV medicine
卷号
12
期号
4
页码范围
211-218
出版商
Blackwell Publishing Ltd
简介
Objectives
The EuResist expert system is a novel data‐driven online system for computing the probability of 8‐week success for any given pair of HIV‐1 genotype and combination antiretroviral therapy regimen plus optional patient information. The objective of this study was to compare the EuResist system vs. human experts (EVE) for the ability to predict response to treatment.
Methods
The EuResist system was compared with 10 HIV‐1 drug resistance experts for the ability to predict 8‐week response to 25 treatment cases derived from the EuResist database validation data set. All current and past patient data were made available to simulate clinical practice. The experts were asked to provide a qualitative and quantitative estimate of the probability of treatment success.
Results
There were 15 treatment successes and 10 treatment failures. In the classification task, the number of mislabelled cases was six for …
学术搜索中的文章
M Zazzi, R Kaiser, A Sönnerborg, D Struck, A Altmann… - HIV medicine, 2011