作者
Paul Dowling, Colin Clarke, Kim Hennessy, Beatriz Torralbo‐Lopez, Jo Ballot, John Crown, Ingrid Kiernan, Kenneth J O'Byrne, M John Kennedy, Vincent Lynch, Martin Clynes
发表日期
2012/8/15
期刊
International journal of cancer
卷号
131
期号
4
页码范围
911-923
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have previously demonstrated that levels of alpha‐2‐heremans‐schmid‐glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) and serum amyloid A (SAA) are significantly altered in serum from patients with squamous cell carcinoma of the lung. Here, we report the abundance levels for these proteins in serum samples from patients with advanced breast cancer, colorectal cancer (CRC) and lung cancer compared to healthy controls (age and gender matched) using commercially available enzyme‐linked immunosorbent assay kits. Logistic regression (LR) models were fitted to the resulting data, and the classification ability of the proteins was evaluated using receiver …
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