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This paper reports a novel approach for the efficient detection of blood and skin cancerous cells using PCF-based sensor. The proposed sensor contains an asymmetrical arrangement of rectangular holes where the core region is composed of a single rectangle. Zeonex is used as the fiber substance. The model is structured and numerically analyzed using the finite element method (FEM)-based software. The simulation of the proposed model validates its efficiency in cancer cell detection. Several performance parameters suggest that the proposed sensor attains optimum results at 2.0 THz. At this point, the sensitivities achieved in detecting blood cancer cells, normal cell (Jurkat), skin cancer cell, normal cell (basal), and water are 96.74, 96.56, 96.61, 96.34, and 95.69%, respectively. Besides, simulation results also suggest that the material and confinement loss are very low for this proposed sensor …