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In this research, the proposed design presents the compact sensing performances while infiltrating the blood fluid in the central hole of the D-shaped elliptical dual-core photonic crystal fiber (PCF) configuration. The properties such as index difference, coupling length, and transmission spectrum pertains the sensing property of the blood plasma cell. The proposed sensor can detect plasma by finite element method (FEM) which can be utilized to detect the variation of plasmon of light using plasma materials.