作者
Michael D Nieskoski, Kayla Marra, Jason R Gunn, P Jack Hoopes, Marvin M Doyley, Tayyaba Hasan, B Stuart Trembly, Brian W Pogue
发表日期
2017/8/30
期刊
Scientific reports
卷号
7
期号
1
页码范围
10093
出版商
Nature Publishing Group UK
简介
The poor efficacy of systemic cancer therapeutics in pancreatic ductal adenocarcinoma (PDAC) is partly attributed to deposition of collagen and hyaluronan, leading to interstitial hypertension collapsing blood and lymphatic vessels, limiting drug delivery. The intrinsic micro-regional interactions between hyaluronic acid (HA), collagen and the spatial origins of mechanical stresses that close off blood vessels was investigated here. Multiple localized pressure measurements were analyzed with spatially-matched histochemical images of HA, collagen and vessel perfusion. HA is known to swell, fitting a linear elastic model with total tissue pressure (TTP) increasing above interstitial fluid pressure (IFP) directly with collagen content. However, local TTP appears to originate from collagen area fraction, as well as increased its entropy and fractal dimension, and morphologically appears to be maximized when HA regions …
学术搜索中的文章
MD Nieskoski, K Marra, JR Gunn, PJ Hoopes… - Scientific reports, 2017