作者
Maureen O Meade, Deborah J Cook, Gordon H Guyatt, Arthur S Slutsky, Yaseen M Arabi, D James Cooper, Andrew R Davies, Lori E Hand, Qi Zhou, Lehana Thabane, Peggy Austin, Stephen Lapinsky, Alan Baxter, James Russell, Yoanna Skrobik, Juan J Ronco, Thomas E Stewart, for the Lung Open Ventilation Study Investigators
发表日期
2008/2/13
期刊
Jama
卷号
299
期号
6
页码范围
637-645
出版商
American Medical Association
简介
Context
Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality.
Objective
To compare an established low-tidal-volume ventilation strategy with an experimental strategy based on the original “open-lung approach,” combining low tidal volume, lung recruitment maneuvers, and high positive-end–expiratory pressure.
Design and Setting
Randomized controlled trial with concealed allocation and blinded data analysis conducted between August 2000 and March 2006 in 30 intensive care units in Canada, Australia, and Saudi Arabia.
Patients
Nine hundred eighty-three consecutive patients with acute lung injury and a ratio of arterial oxygen tension to inspired oxygen fraction not exceeding 250.
Interventions
The control strategy included target tidal volumes of …
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