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Three rapid, sensitive, and simple spectrophotometric methods have been developed for the determination of pioglitazone in pure and pharmaceutical preparations.

For the first method, UV-spectrophotometry, standard solutions were measured at 270.2 nm. The first method was linear from 5.0–20.0 µgmL⁻¹. The linearity was found to be 5.0–20.0 µgmL⁻¹. For the second method, the distances between two extremum values (peak-to-peak amplitudes), 272.0 and 287.4 nm were measured in the second order derivative-spectra of standard solutions. Calibration curves were constructed by plotting d² A/dλ² values against concentrations, 2.0–12.0 µgmL⁻¹ of pioglitazone standards in acetonitrile. The detection limits of pioglitazone were 0.10 and 0.16 µgmL⁻¹ for UV and derivative spectrophotometric methods, respectively. The third method was based on the formation of an ion association …