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Deep learning-based object detection and instance segmentation have achieved unprecedented progress. In this article, we propose complete-IoU (CIoU) loss and Cluster-NMS for enhancing geometric factors in both bounding-box regression and nonmaximum suppression (NMS), leading to notable gains of average precision (AP) and average recall (AR), without the sacrifice of inference efficiency. In particular, we consider three geometric factors, that is: 1) overlap area; 2) normalized central-point distance; and 3) aspect ratio, which are crucial for measuring bounding-box regression in object detection and instance segmentation. The three geometric factors are then incorporated into CIoU loss for better distinguishing difficult regression cases. The training of deep models using CIoU loss results in consistent AP and AR improvements in comparison to widely adopted -norm loss and IoU-based loss …