作者
Karin Welén, Ebba Rosendal, Magnus Gisslén, Annasara Lenman, Eva Freyhult, Osvaldo Fonseca-Rodríguez, Daniel Bremell, Johan Stranne, Åse Östholm Balkhed, Katarina Niward, Johanna Repo, David Robinsson, Anna J Henningsson, Johan Styrke, Martin Angelin, Elisabeth Lindquist, Annika Allard, Miriam Becker, Stina Rudolfsson, Robert Buckland, Camilla Thellenberg Carlsson, Anders Bjartell, Anna C Nilsson, Clas Ahlm, Anne-Marie Fors Connolly, Anna K Överby, Andreas Josefsson
发表日期
2022/3/1
期刊
European urology
卷号
81
期号
3
页码范围
285-293
出版商
Elsevier
简介
Background
Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response.
Objective
To clinically, epidemiologically, and experimentally evaluate the effect of antiandrogens on SARS-CoV-2 infection.
Designs, settings, and participants
A randomized phase 2 clinical trial (COVIDENZA) enrolled 42 hospitalized COVID-19 patients before safety evaluation. We also conducted a population-based retrospective study of 7894 SARS-CoV-2–positive prostate cancer patients and an experimental study using an air-liquid interface three-dimensional culture model of primary lung cells.
Intervention
In COVIDENZA, patients were randomized 2:1 to 5 d of enzalutamide or standard of care.
Outcome measurements
The primary outcomes in COVIDENZA were the time to mechanical ventilation or discharge from hospital. The population-based study investigated risk of …
学术搜索中的文章
K Welén, E Rosendal, M Gisslén, A Lenman, E Freyhult… - European urology, 2022