查看文章

The coagulation system is part of the innate immune response and is activated in response to viral infection [1]. A variety of viruses, such as HIV, Coxsackievirus, Dengue virus and Ebola virus have been shown to induce tissue factor (TF) expression in infected cells, such as monocytes and endothelial cells [1]. This leads to activation of the coagulation system and disseminated intravascular coagulation (DIC). Indeed, inhibition of TF was shown to prevent activation of coagulation in primates infected with either Ebola virus or simian immunodeficiency virus [2, 3].

Orthohantaviruses are rodent-borne, negative stranded, RNA viruses that belong to the Hantaviridae family and Bunyavirales order. Orthohantavirus infection in North and South America causes hantavirus cardiopulmonary syndrome (HCPS)[4]. The pathogenesis of HCPS is poorly understood but includes thrombocytopenia, capillary leakage and non …