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In the present study, a novel fractional Meyer neuro-evolution-based intelligent computing solver (FMNEICS) is presented for numerical treatment of doubly singular multi-fractional Lane–Emden system (DSMF-LES) using combined heuristics of Meyer wavelet neural networks (MWNN) optimized with global search efficacy of genetic algorithms (GAs) and sequential quadratic programming (SQP), i.e., MWNN-GASQP. The design of novel FMNEICS for DSMF-LES is presented after derivation from standard Lane–Emden equation, and the singular points and shape factors along with fractional-order terms are analyzed. The MWNN modeling strength is used to represent the system model DSMF-LES in the mean-squared error-based merit function and optimization of the networks is carried out with integrated optimization ability of GASQP. The verification, validation, and perfection of the FMNEICS for three …