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Despite its widespread adoption and popularity, the Hypertext Transfer Protocol (HTTP) suffers from fundamental performance limitations. SPDY, a recently proposed alternative to HTTP, tries to address many of the limitations of HTTP (e.g., multiple connections, setup latency). With cellular networks fast becoming the communication channel of choice, we perform a detailed measurement study to understand the benefits of using SPDY over cellular networks. Through careful measurements conducted over four months, we provide a detailed analysis of the performance of HTTP and SPDY, how they interact with the various layers, and their implications on web design. Our results show that unlike in wired and 802.11 networks, SPDY does not clearly outperform HTTP over cellular networks. We identify, as the underlying cause, a lack of harmony between how TCP and cellular networks interact. In particular, the …