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Spatial and social dependence shape human activity-travel pattern decisions and their antecedent choices. Although the transportation literature has long recognized the importance of considering spatial and social dependencies in modeling individuals’ choice behavior, there has been less research on techniques to accommodate these dependencies in discrete choice models, mainly because of the modeling complexities introduced by such interdependencies. The main goal of this dissertation, therefore, is to propose new modeling approaches for accommodating flexible spatial and social dependency structures in discrete choice models within the broader context of activity-based travel demand modeling. The primary objectives of this dissertation research are three-fold. The first objective is to develop a discrete choice modeling methodology that explicitly incorporates spatial dependency (or correlation) across location choice alternatives (whether the choice alternatives are contiguous or non-contiguous). This is achieved by incorporating flexible spatial correlations and patterns using a closed-form Generalized Extreme Value (GEV) structure. The second objective is to propose new approaches to accommodate spatial dependency (or correlation) across observational units for different aspatial discrete choice models, including binary choice and ordered-response choice models. This is achieved by adopting different copula-based methodologies, which offer flexible dependency structures to test for different forms of dependencies. Further, simple and practical approaches are proposed, obviating the need for any kind of simulation …