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Background: Pediatric pulmonary embolism (PE) is rare in children, but the incidence is rising. Despite the associated significant morbidity and mortality, there is limited data to guide the care of children and adolescents who present with PE. There is a demonstrated need to standardize evaluation and management of pediatric PE, and for further research to investigate the safety and efficacy of therapeutic options.

Aims: The primary aim was to describe the clinical characteristics of pediatric patients presenting with acute PE. Secondary aims were to describe the treatment of pediatric PE and to define bleeding complications in those who received systemic thrombolysis.

Methods: A single center, retrospective review was performed including patients< 21 years of age who received primary treatment for acute PE at the Children's Hospital of Philadelphia (CHOP) between 1/1/2003 and 8/1/2021. Patients were initially …