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Objective: Alarm fatigue is a widely recognized safety and quality problem where exposure to high rates of clinical alarms results in desensitization leading to dismissal of or slowed response to alarms. Nonactionable alarms are thought to be especially problematic. Despite these concerns, the number of clinical alarm signals has been increasing as an everincreasing number of medical technologies are added to the clinical care environment.

Data Sources: PubMed, SCOPUS, Embase, and CINAHL.

Study Selection: We performed a systematic review of the literature focused on clinical alarms. We asked a primary key question;“what interventions have been attempted and resulted in the success of reducing alarm fatigue?” and 3-secondary key questions;“what are the negative effects on patients/families; what are the balancing outcomes (unintended consequences of interventions); and what human factor …