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Chronic Kidney Disease (CKD) has become a major problem in modern times, and it is dubbed the silent assassin due to its delayed signs. To overcome these critical issues, early identification may minimize the prevalence of chronic diseases, though it is quite difficult because of different kinds of limitations in the dataset. The novelty of our study is that we extracted the best features from the dataset in order to provide the best classification models for diagnosing patients with chronic kidney disease. In our study, we used CKD patients’ clinical datasets to predict CKD using some popular machine learning algorithms. After handling missing values, K-means clustering has been performed. Then feature selection was done by applying the XGBoost feature selection algorithm. After selecting features from our dataset, we have used a variety of machine learning models to determine the best classification models …