作者
Natasha Kishore Pahuja, Rohit Shetty, Rashmi Deshmukh, Anupam Sharma, Rudy MMA Nuijts, Vishal Jhanji, Swaminathan Sethu, Arkasubhra Ghosh
发表日期
2017/12/1
期刊
British Journal of Ophthalmology
卷号
101
期号
12
页码范围
1604-1610
出版商
BMJ Publishing Group Ltd
简介
Aim
Corneal keratectasia is one of the complications associated with laser in situ keratomileusis (LASIK) that results in vision impairment. The pathogenesis of post-LASIK ectasia (PLE) remains underexplored. We report the tear cytokine profile and in vivo confocal microscopy (IVCM) findings in eyes with PLE.
Methods
This retrospective study included age-matched 7 (14 eyes) post-LASIK controls (PLCs) and 6 (12 eyes) PLE subjects. Corneal topography was used to categorise the subjects into PLC and PLE groups. Ocular Surface Disease Index (OSDI) scores obtained were based on standard questionnaire and IVCM images were used to determine corneal dendritic cells density (DCD) and sub-basal nerve plexus morphology. Inflammatory cytokines/chemokines in the tears were quantified using flow cytometry based cytometric bead array.
Results
Pentacam-based scores, OSDI scores and corneal DCD were …
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NK Pahuja, R Shetty, R Deshmukh, A Sharma… - British Journal of Ophthalmology, 2017