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Background:

Aggressive periodontitis (AgP) has been associated with polymorphonuclear leukocyte's (PMNL) dysfunction and periodontal pathogens possess variety of virulence factors that can impair PMNL's function. This study investigated the possible association between defective neutrophil adhesion and β 2-integrin expression and defective neutrophil migration and actin polymerization level in the peripheral blood of neutrophils from the patients with AgP.

Materials and Methods:

A total of 30 individuals both male and female, age ranges between 13–48 years, were included in the study. Healthy controls (group I, n= 10), chronic periodontitis (ChP)(group II, n= 10), and AgP (group III, n= 10), all without any systemic diseases and non-smokers, were recruited. Peripheral blood samples were taken and β 2-integrin expression and actin polymerization levels were estimated by using fluorescence activated cell …