作者
José Pinto-Fraga, Alberto López-Miguel, María J González-García, Itziar Fernández, Alberto López-de-la-Rosa, Amalia Enríquez-de-Salamanca, Michael E Stern, Margarita Calonge
发表日期
2016/1/31
期刊
Ophthalmology
卷号
123
期号
1
页码范围
141-153
出版商
Elsevier
简介
Purpose
To assess the efficacy of topical 0.1% fluorometholone in dry eye disease (DED) patients for ameliorating the worsening of the ocular surface when exposed to adverse environments.
Design
Single-center, double-masked, randomized, vehicle-controlled clinical trial.
Participants
Forty-one patients showing moderate to severe DED.
Methods
Patients randomly received 1 drop 4 times daily of either topical 0.1% fluorometholone (FML group) or topical polyvinyl alcohol (PA group) for 22 days. Corneal and conjunctival staining, conjunctival hyperemia, tear film breakup time (TBUT), tear osmolarity, and the Symptom Assessment in Dry Eye (SANDE) questionnaire scores were determined at baseline. Variables were reassessed on day 21 before and after undergoing a 2-hour controlled adverse environment exposure and again on day 22.
Main Outcomes Measures
Percentage of patients showing an increase 1 …
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J Pinto-Fraga, A López-Miguel, MJ González-García… - Ophthalmology, 2016