作者
Michael Putman, Yu Pei Eugenia Chock, Herman Tam, Alfred HJ Kim, Sebastian E Sattui, Francis Berenbaum, Maria I Danila, Peter Korsten, Catalina Sanchez-Alvarez, Jeffrey A Sparks, Laura C Coates, Candace Palmerlee, Andrea Peirce, Arundathi Jayatilleke, Sindhu R Johnson, Adam Kilian, Jean Liew, Larry J Prokop, M Hassan Murad, Rebecca Grainger, Zachary S Wallace, Ali Duarte-Garcia, COVID‐19 Global Rheumatology Alliance
发表日期
2021/1
来源
Arthritis & Rheumatology
卷号
73
期号
1
页码范围
36-47
简介
Objective
Antirheumatic disease therapies have been used to treat coronavirus disease 2019 (COVID‐19) and its complications. We conducted a systematic review and meta‐analysis to describe the current evidence.
Methods
A search of published and preprint databases in all languages was performed. Included studies described ≥1 relevant clinical outcome for ≥5 patients who were infected with severe acute respiratory syndrome coronavirus 2 and were treated with antirheumatic disease therapy between January 1, 2019 and May 29, 2020. Pairs of reviewers screened articles, extracted data, and assessed risk of bias. A meta‐analysis of effect sizes using random‐effects models was performed when possible.
Results
The search identified 3,935 articles, of which 45 were included (4 randomized controlled trials, 29 cohort studies, and 12 case series). All studies evaluated hospitalized patients, and 29 of the …
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