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Several methods for heat exchanger networks (HEN) design are based on the use of superstructures. The models they give rise to can lead to different design options to be explored in HEN synthesis. In this work, a stage-wise superstructure with new features for the optimal placement of heaters and coolers, including the possibility of the use of multiple utilities, is presented. In the model, those units can be placed in different stream split branches in all stages, differing from the usual allocation at stream ends. Such possibilities yield a more complex mathematical model. To solve it, an improved version of a previously presented hybrid meta-heuristic method was used. Three examples from the literature were studied. The use of the superstructure with the additional utility-related options, as well as the enhanced meta-heuristic solution method, led to configurations with lower associated total annual costs than those …