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This paper aims to provide reliable indications of driver drowsiness based on the characteristics of driver-vehicle interaction. A test bed was built under a simulated driving environment, and a total of 12 subjects participated in two experiment sessions requiring different levels of sleep (partial sleep-deprivation versus no sleep-deprivation) before the experiment. The performance of the subjects was analyzed in a series of stimulus-response and routine driving tasks, which revealed the performance differences of drivers under different sleep-deprivation levels. The experiments further demonstrated that sleep deprivation had greater effect on rule-based than on skill-based cognitive functions: when drivers were sleep-deprived, their performance of responding to unexpected disturbances degraded, while they were robust enough to continue the routine driving tasks such as lane tracking, vehicle following, and lane …