作者
Massimo Bocchio, Giovambattista Desideri, Piero Scarpelli, Stefano Necozione, Giuliana Properzi, Carlo Spartera, Felice Francavilla, Claudio Ferri, Sandro Francavilla
发表日期
2004/4
期刊
The Journal of urology
卷号
171
期号
4
页码范围
1601-1604
出版商
Wolters Kluwer
简介
Purpose
Endothelial cell activation (ECA) is an initiating event in atherosclerosis. Biochemical measures of ECA were evaluated in patients with erectile dysfunction (ED) associated or not associated with cardiovascular risk factors (VRFs) to assess whether ED is a sentinel of atherosclerosis.
Materials and Methods
Circulating soluble P-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and endothelin-1 concentrations were assessed in 45 men with ED but no VRFs, 45 men with ED associated with VRFs and 25 healthy men. Ultrasound intima-media thickness of carotid arteries and pharmacologically stimulated peak systolic velocity of cavernous arteries were used to assess vascular damage.
Results
Measures of ECA were higher in men with ED but no VRFs than in controls (p <0.01) and all were comparable among groups of men with ED. Levels of endothelin-1 in men with ED and no …
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