作者
Jianfeng Wang, Chen Wang, Pan Xu, Xiao Li, Yongning Lu, Di Jin, Xiaomao Yin, Hao Jiang, Jing Huang, Huan Xiong, Fei Ye, Jia Jin, Yu Chen, Yiqian Xie, Zhifeng Chen, Hong Ding, Hao Zhang, Rongfeng Liu, Hualiang Jiang, Kaixian Chen, Zhiyi Yao, Cheng Luo, Yiran Huang, Yuanyuan Zhang, Jin Zhang
发表日期
2021
期刊
Theranostics
卷号
11
期号
11
页码范围
5387
出版商
Ivyspring International Publisher
简介
Background and Objective: Epigenetic alterations are common events in clear cell renal cell carcinoma (ccRCC), and protein arginine methyltransferase 1 (PRMT1) is an important epigenetic regulator in cancers. However, its role in ccRCC remains unclear.
Methods: We investigated PRMT1 expression level and its correlations to clinicopathological factors and prognosis in ccRCC patients based on ccRCC tissue microarrays (TMAs). Genetic knockdown and pharmacological inhibition using a novel PRMT1 inhibitor DCPT1061 were performed to investigate the functional role of PRMT1 in ccRCC proliferation. Besides, we confirmed the antitumor effect of PRMT1 inhibitor DCPT1061 in ccRCC cell-derived tumor xenograft (CDX) models as well as patient-derived tumor xenograft (PDX) models.
Results: We found PRMT1 expression was remarkably upregulated in tumor tissues and associated with poor pathologic …
学术搜索中的文章
J Wang, C Wang, P Xu, X Li, Y Lu, D Jin, X Yin, H Jiang… - Theranostics, 2021