作者
Chengzhang Shi, Zhao Ye, Jie Han, Xiaoqing Ye, Wenchao Lu, Chenxing Ji, Zizhou Li, Zengyi Ma, Qilin Zhang, Yichao Zhang, Wenqiang He, Zhengyuan Chen, Xiaoyun Cao, Xuefei Shou, Xiang Zhou, Yongfei Wang, Zhaoyun Zhang, Yiming Li, Hongying Ye, Min He, Hong Chen, Haixia Cheng, Jun Sun, Jianyong Cai, Chuanxin Huang, Fei Ye, Cheng Luo, Bing Zhou, Hong Ding, Yao Zhao
发表日期
2020/8/17
期刊
Neuro-oncology
卷号
22
期号
8
页码范围
1114-1125
出版商
Oxford University Press
简介
Background
Nonfunctioning pituitary adenoma (NFPA) and growth hormone pituitary adenoma (GHPA) are major subtypes of pituitary adenomas (PAs). The primary treatment is surgical resection. However, radical excision remains challenging, and few effective medical therapies are available. It is urgent to find novel targets for the treatment. Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator that leads to aberrant transcriptional activation of oncogenes. Herein, we investigated the pathological role of BRD4 and evaluated the effectiveness of BRD4 inhibitors in the treatment of NFPA and GHPA.
Methods
The expression of BRD4 was detected in NFPA, GHPA, and normal pituitary tissues. The efficacies of BRD4 inhibitors were evaluated in GH3 and MMQ cell lines, patient-derived tumor cells, and in vivo mouse xenograft models of PA. Standard western blots …
学术搜索中的文章
C Shi, Z Ye, J Han, X Ye, W Lu, C Ji, Z Li, Z Ma… - Neuro-oncology, 2020