作者
Rishi R Goel, Mark M Painter, Sokratis A Apostolidis, Divij Mathew, Wenzhao Meng, Aaron M Rosenfeld, Kendall A Lundgreen, Arnold Reynaldi, David S Khoury, Ajinkya Pattekar, Sigrid Gouma, Leticia Kuri-Cervantes, Philip Hicks, Sarah Dysinger, Amanda Hicks, Harsh Sharma, Sarah Herring, Scott Korte, Amy E Baxter, Derek A Oldridge, Josephine R Giles, Madison E Weirick, Christopher M McAllister, Moses Awofolaju, Nicole Tanenbaum, Elizabeth M Drapeau, Jeanette Dougherty, Sherea Long, Kurt D’Andrea, Jacob T Hamilton, Maura McLaughlin, Justine C Williams, Sharon Adamski, Oliva Kuthuru, UPenn COVID Processing Unit‡, Ian Frank, Michael R Betts, Laura A Vella, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Scott E Hensley, Miles P Davenport, Paul Bates, Eline T Luning Prak, Allison R Greenplate, E John Wherry
发表日期
2021/10/14
期刊
Science
卷号
374
期号
6572
页码范围
abm0829
出版商
American Association for the Advancement of Science
简介
INTRODUCTION
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines are highly effective at preventing infection and especially severe disease. However, the emergence of variants of concern (VOCs) and increasing infections in vaccinated individuals have raised questions about the durability of immunity after vaccination.
RATIONALE
To study immune memory, we longitudinally profiled antigen-specific antibody, memory B cell, and memory T cell responses in 61 individuals receiving mRNA vaccines from baseline to 6 months postvaccination. A subgroup of 16 individuals had recovered from prior SARS-CoV-2 infection, providing insight into boosting preexisting immunity with mRNA vaccines.
RESULTS
mRNA vaccination induced robust anti-spike, anti–receptor binding domain (RBD), and neutralizing antibodies that remained above prevaccine baseline levels in most individuals …
学术搜索中的文章
RR Goel, MM Painter, SA Apostolidis, D Mathew… - Science, 2021