作者
Feilong Lu, Haimei Lu, Meijuan Xie, Shan Li, Yunyun Zu, Jia Zhou, Jie Yu, Shuang Wang, Yeping Ruan, Chengping Wen, Zhenghao Xu
发表日期
2019/6/1
期刊
Inflammopharmacology
卷号
27
期号
3
页码范围
511-520
出版商
Springer International Publishing
简介
Objective
To investigate whether glucocorticoids, the hallmark medication for systemic lupus erythematosus (SLE), could prevent the development of neuropsychiatric SLE (NPSLE).
Methods
The protective effects of prednisone on NPSLE were tested using the open field, object recognition/placement, forced swim, tail suspension, and sucrose preference tests in MRL/lpr mice. Auto-antibody titres and the weight of lymph nodes were also measured.
Results
MRL/lpr mice exhibited mild depression at the age of 8 weeks before progressing with spatial cognitive impairment and severe depression-like behaviour at the age of 16 weeks. Treating MRL/lpr mice with prednisone (5 mg/kg) from the age of 8 weeks decreased anti-cardiolipin and anti-N-methyl-d-aspartate (NMDA) receptor antibody titres in the brain, reduced the …
学术搜索中的文章
F Lu, H Lu, M Xie, S Li, Y Zu, J Zhou, J Yu, S Wang… - Inflammopharmacology, 2019