作者
Jia Zhou, Feilong Lu, Shan Li, Meijuan Xie, Haimei Lu, Zhijun Xie, Dehong Wu, Shuang Wang, Chengping Wen, Zheng-Hao Xu
发表日期
2020/4
期刊
Inflammopharmacology
卷号
28
期号
2
页码范围
425-435
出版商
Springer International Publishing
简介
Objective
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a common cause of disability in systemic lupus erythematosus (SLE). This study aims to investigate the metabolic changes in the hypothalamus and frontal cortex in lupus-prone MRL/lpr mice.
Methods
Metabolic changes were analyzed using gas chromatography-mass spectrometry (GC–MS).
Results
According to the principal component analysis (PCA), the metabolic profiles were different between the frontal cortex and hypothalamus, but they were comparable between MRL/lpr and MRL/MpJ mice (16 weeks of age). By OPLS-DA, eight cortical and six hypothalamic differential metabolites were identified in MRL/lpr as compared to MRL/MpJ mice. Among these differential metabolites, we found a decrease of N-acetyl-l-aspartate (NAA, a potential …
学术搜索中的文章
J Zhou, F Lu, S Li, M Xie, H Lu, Z Xie, D Wu, S Wang… - Inflammopharmacology, 2020