作者
Ying Wang, Yi Wang, Cenglin Xu, Shuang Wang, Na Tan, Cong Chen, Liying Chen, Xiaohua Wu, Fan Fei, Heming Cheng, Wenkai Lin, Yingbei Qi, Bin Chen, Jiao Liang, Junli Zhao, Zhenghao Xu, Yi Guo, Shihong Zhang, Xiaoming Li, Yudong Zhou, Shumin Duan, Zhong Chen
发表日期
2020/5/1
期刊
Biological psychiatry
卷号
87
期号
9
页码范围
843-856
出版商
Elsevier
简介
Background
Previous studies indicated the involvement of cholinergic neurons in seizure; however, the specific role of the medial septum (MS)-hippocampus cholinergic circuit in temporal lobe epilepsy (TLE) has not yet been completely elucidated.
Methods
In the current study, we used magnetic resonance imaging and diffusion tensor imaging to characterize the pathological change of the MS-hippocampus circuit in 42 patients with TLE compared with 22 healthy volunteers. Using optogenetics and chemogenetics, combined with in vivo or in vitro electrophysiology and retrograde rabies virus tracing, we revealed a direct MS-hippocampus cholinergic circuit that potently attenuates seizure through driving somatostatin inhibition in animal TLE models.
Results
We found that patients with TLE with hippocampal sclerosis showed a decrease of neuronal fiber connectivity of the MS-hippocampus compared with healthy …
学术搜索中的文章
Y Wang, YI Wang, C Xu, S Wang, N Tan, C Chen… - Biological Psychiatry, 2020