作者
Wesley H Self, Robert A Balk, Carlos G Grijalva, Derek J Williams, Yuwei Zhu, Evan J Anderson, Grant W Waterer, D Mark Courtney, Anna M Bramley, Christopher Trabue, Sherene Fakhran, Anne J Blaschke, Seema Jain, Kathryn M Edwards, Richard G Wunderink
发表日期
2017/7/15
期刊
Clinical Infectious Diseases
卷号
65
期号
2
页码范围
183-190
出版商
Oxford University Press
简介
Background
Recent trials suggest procalcitonin-based guidelines can reduce antibiotic use for respiratory infections. However, the accuracy of procalcitonin to discriminate between viral and bacterial pneumonia requires further dissection.
Methods
We evaluated the association between serum procalcitonin concentration at hospital admission with pathogens detected in a multicenter prospective surveillance study of adults hospitalized with community-acquired pneumonia. Systematic pathogen testing included cultures, serology, urine antigen tests, and molecular detection. Accuracy of procalcitonin to discriminate between viral and bacterial pathogens was calculated.
Results
Among 1735 patients, pathogens were identified in 645 (37%), including 169 (10%) with typical bacteria, 67 (4%) with atypical bacteria, and 409 (24%) with viruses only. Median …
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WH Self, RA Balk, CG Grijalva, DJ Williams, Y Zhu… - Clinical Infectious Diseases, 2017