作者
Andrea H Ramirez, Lina Sulieman, David J Schlueter, Alese Halvorson, Jun Qian, Francis Ratsimbazafy, Roxana Loperena, Kelsey Mayo, Melissa Basford, Nicole Deflaux, Karthik N Muthuraman, Karthik Natarajan, Abel Kho, Hua Xu, Consuelo Wilkins, Hoda Anton-Culver, Eric Boerwinkle, Mine Cicek, Cheryl R Clark, Elizabeth Cohn, Lucila Ohno-Machado, Sheri D Schully, Brian K Ahmedani, Maria Argos, Robert M Cronin, Christopher O’Donnell, Mona Fouad, David B Goldstein, Philip Greenland, Scott J Hebbring, Elizabeth W Karlson, Parinda Khatri, Bruce Korf, Jordan W Smoller, Stephen Sodeke, John Wilbanks, Justin Hentges, Stephen Mockrin, Christopher Lunt, Stephanie A Devaney, Kelly Gebo, Joshua C Denny, Robert J Carroll, David Glazer, Paul A Harris, George Hripcsak, Anthony Philippakis, Dan M Roden, Brian Ahmedani, Christine D Cole Johnson, Habib Ahsan, Donna Antoine-LaVigne, Glendora Singleton, Eric Topol, Katie Baca-Motes, Steven Steinhubl, James Wade, Mark Begale, Praduman Jain, Scott Sutherland, Beth Lewis, Melissa Behringer, Ali G Gharavi, Louise Bier, Murray H Brilliant, Narayana Murali, Scott Joseph Hebbring, Dorothy Farrar-Edwards, Elizabeth Burnside, Marc K Drezner, Amy Taylor, Veena Channamsetty, Wanda Montalvo, Yashoda Sharma, Carmen Chinea, Nancy Jenks, Steve Thibodeau, Beverly Wilson Holmes, Eric Schlueter, Ever Collier, Joyce Winkler, John Corcoran, Nick D’Addezio, Martha Daviglus, Robert Winn, Dan Roden, Joshua Denny, Kim Doheny, Debbie Nickerson, Evan Eichler, Gail Jarvik, Gretchen Funk, Heidi Rehm, Niall Lennon, Sekar Kathiresan, Stacey Gabriel, Richard Gibbs, Edgar M Gil Rico, Joannie Grand, Paul Harris, Elizabeth Shenkman, William R Hogan, Priscilla Igho-Pemu, Cliff Pollan, Milena Jorge, Sally Okun, Jordan Smoller, Shawn N Murphy, Margaret Elizabeth Ross, Rainu Kaushal, Eboni Winford, Febe Wallace, Vik Kheterpal, Akinlolu Ojo, Francisco A Moreno, Irving Kron, Rachele Peterson, Usha Menon, Patricia Watkins Lattimore, Noga Leviner, Juno Obedin-Maliver, Mitchell Lunn, Lynda Malik-Gagnon, Lara Mangravite, Adria Marallo, Oscar Marroquin, Shyam Visweswaran, Steven Reis, Gailen Marshall, Patrick McGovern, Deb Mignucci, John Moore, Fatima Munoz, Gregory Talavera, George T O'Connor, Christopher O'Donnell, Greg Orr, Fornessa Randal, Andreas A Theodorou, Eric Reiman, Mercedita Roxas-Murray, Louisa Stark, Ronnie Tepp, Alicia Zhou, Scott Topper, Rhonda Trousdale, Phil Tsao, Lisa Weidman, Scott T Weiss, David Wellis
发表日期
2022/8/12
期刊
Patterns
卷号
3
期号
8
出版商
Elsevier
简介
The All of Us Research Program seeks to engage at least one million diverse participants to advance precision medicine and improve human health. We describe here the cloud-based Researcher Workbench that uses a data passport model to democratize access to analytical tools and participant information including survey, physical measurement, and electronic health record (EHR) data. We also present validation study findings for several common complex diseases to demonstrate use of this novel platform in 315,000 participants, 78% of whom are from groups historically underrepresented in biomedical research, including 49% self-reporting non-White races. Replication findings include medication usage pattern differences by race in depression and type 2 diabetes, validation of known cancer associations with smoking, and calculation of cardiovascular risk scores by reported race effects. The cloud-based …
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AH Ramirez, L Sulieman, DJ Schlueter, A Halvorson… - Patterns, 2022