作者
Stephanos Christodoulides, Eirini Dimidi, Konstantinos C Fragkos, Adam D Farmer, Kevin Whelan, S Mark Scott
发表日期
2016/7
来源
Alimentary pharmacology & therapeutics
卷号
44
期号
2
页码范围
103-116
简介
Background
Chronic idiopathic constipation is a common symptom‐based gastrointestinal disorder responsible for a substantial economic health service burden. Current guidelines recommend the use of fibre as a first‐line treatment.
Aim
To investigate the effect of fibre (including prebiotic) supplementation on global symptom response, stool output, gut microbiota composition and adverse events in adults with chronic idiopathic constipation.
Methods
Medline, EmBase, Web of Science, Scopus and the Cochrane central register of controlled trials were searched through to February 2016. Conference proceedings from 2003 to 2015 were hand‐searched. There were no language restrictions. Forest plots with 95% CIs were generated using a random‐effects model.
Results
The search strategy generated 1072 citations, of which seven individual randomised controlled trials were eligible. Overall, 113 of 147 (77 …
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