查看文章

Irritable bowel syndrome is a widespread disorder with a marked socioeconomic burden. Previous studies support the proposal that a subset of patients with features compatible with diarrhoea‐predominant IBS (IBS‐D) have bile acid malabsorption (BAM).

To perform a systematic review and meta‐analysis to assess the prevalence of BAM in patients meeting the accepted criteria for IBS‐D.

MEDLINE and EMBASE were searched up to March 2015. Studies recruiting adults with IBS‐D, defined by the Manning, Kruis, Rome I, II or III criteria and which used 23‐seleno‐25‐homotaurocholic acid (SeHCAT) testing for the assessment of BAM were included. BAM was defined as 7 day SeHCAT retention of <10%. We calculated the rate of BAM and 95% confidence intervals (CI) using a random effects model. The methodological quality of included studies was evaluated using the Quality …