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ECG monitoring systems have a significant role in detecting cardiovascular diseases and reducing the rate of sudden cardiac deaths. One of the critical factors to support real-time ECG tracking is to guarantee monitoring system availability. Hence, this work targets battery life expansion for a 12 Lead ECG patch. ECG patch operational hours are extended by reducing Bluetooth Low Energy (BLE) communication airtime, hence reducing the overall transmission power and extending the battery life. Huffman, delta, and base-delta compression techniques are implemented on a Texas Instruments CC2650 Microcontroller Unit using different sampling rates and cardiac conditions such as normal, ventricular tachycardia, and ventricular fibrillation state. The performance of each encoding algorithm is evaluated in terms of compression ratio, the execution time, and power consumption of the ECG patch. Our findings show …