作者
Tim B Bigdeli, Stephan Ripke, Roseann E Peterson, Maciej Trzaskowski, Silviu-Alin Bacanu, Abdel Abdellaoui, TFM Andlauer, ATF Beekman, Klaus Berger, Douglas HR Blackwood, Dorret I Boomsma, G Breen, HN Buttenschøn, EM Byrne, S Cichon, Toni-Kim Clarke, B Couvy-Duchesne, Nicholas Craddock, Eco JC de Geus, F Degenhardt, Erin C Dunn, AC Edwards, Ayman H Fanous, AJ Forstner, J Frank, M Gill, Scott D Gordon, Hans J Grabe, Steven P Hamilton, Orla Hardiman, Caroline Hayward, Andrew C Heath, Anjali K Henders, S Herms, Ian B Hickie, P Hoffmann, Georg Homuth, Jouke-Jan Hottenga, M Ising, R Jansen, S Kloiber, James A Knowles, M Lang, QS Li, S Lucae, Donald J Macintyre, Pamela AF Madden, NG Martin, Patrick J McGrath, P McGuffin, Andrew M McIntosh, SE Medland, D Mehta, Christel M Middeldorp, Yuri Milaneschi, GW Montgomery, O Mors, B Müller-Myhsok, M Nauck, Dale R Nyholt, Markus M Nöthen, MJ Owen, Brenda WJH Penninx, Michele L Pergadia, RH Perlis, WJ Peyrot, DJ Porteous, James B Potash, John P Rice, M Rietschel, Brien P Riley, M Rivera, R Schoevers, TG Schulze, J Shi, Stanley I Shyn, JH Smit, Jordan W Smoller, Fabian Streit, J Strohmaier, Alexander Teumer, J Treutlein, Sandra Van der Auwera, Gerard Van Grootheest, AM Van Hemert, Henry Völzke, Bradley Todd Webb, Myrna M Weissman, Juergen Wellmann, Gonneke Willemsen, SH Witt, Douglas F Levinson, CM Lewis, Naomi R Wray, J Flint, PF Sullivan, Kenneth S Kendler
发表日期
2017/3
期刊
Translational psychiatry
卷号
7
期号
3
页码范围
e1074-e1074
出版商
Nature Publishing Group
简介
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~ 30–40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects. We determined the fraction of SNPs displaying consistent directions of effect, assessed the significance of polygenic risk scores and estimated the genetic correlation of MDD across ancestries. Subsequent trans-ancestry meta-analyses combined SNP-level evidence of association. Sign tests and polygenic score profiling weakly support an overlap of SNP …
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TB Bigdeli, S Ripke, RE Peterson, M Trzaskowski… - Translational psychiatry, 2017