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Cytotoxic and antimutagenic effects of a novelcis-ε-viniferin and five known stilbenes,trans-resveratrol,frans-ε-viniferin, gnetin H, suffruticosols A and B, isolated from the seeds ofPaeonia lactiflora Pall. (Paeoniaceae) were determined against five different cancer cell lines, and mutagenicity ofN-methyl-N'-nitro-N-nitrosoguanidine (MNNG) inSalmonella typhimurium TA100, respectively. Six stilbenes showed cytotoxic activity in a dose-dependent manner, and especially did potent cytotoxic activity against C6 (mouse glioma) cancer cell with IC₅₀ values ranging from 8.2 to 20.5 ug/ml.trans-Resveratrol showed significant cytotoxic activity against HepG2 (liver hepatoma) and HT-29 (colon) human cancer cell lines with IC₅₀ values of 11.8 and 25.2 g/ml, respectively. In contrast,trans-ε-viniferin andcis--viniferin, and gnetin H exhibited marked cytotoxic activity against Hela (cervicse) and MCF-7 (breast) human …