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To recognize the basis of disease, it is essential to determine its underlying genes. Understanding the association between underlying genes and genetic disease is a fundamental problem regarding human health. Identification and association of genes with the disease require time consuming and expensive experimentations of a great number of potential candidate genes. Therefore, the alternative inexpensive and rapid computational methods have been proposed that can identify the candidate gene associated with a disease. Most of these methods use phenotypic similarities due to the fact that genes causing same or similar diseases have less variation in their sequence or network properties of protein-protein interactions based on-premises that genes lie closer in protein interaction network that causes the similar or same disease. However, these methods use only basic network properties or topological …