作者
Pierre Charbonneau, Jean-Jacques Parienti, Pascal Thibon, Michel Ramakers, Cédric Daubin, Damien du Cheyron, Guy Lebouvier, Xavier Le Coutour, Roland Leclercq, French Fluoroquinolone Free (3F) Study Group
发表日期
2006/3/15
期刊
Clinical infectious diseases
卷号
42
期号
6
页码范围
778-784
出版商
The University of Chicago Press
简介
Background . We investigated the possible association between fluoroquinolone use and the rate of methicillin-resistant Staphylococcus aureus (MRSA) recovery from consecutive hospitalized patients.
Methods . We conducted a nonrandomized, prospective, controlled interventional “fluoroquinolone-free” study at 4 large teaching hospitals in northwest France, catering to a total of 5,882,600 persons. During the intervention period (January through December 2001), fluoroquinolone use was prohibited at 1 of the 4 hospitals (Caen Hospital), unless no effective alternative was available. Three university hospitals were used as controls because they had similar preintervention rates of MRSA.
Results . During the intervention period (2001), the annual rate of fluoroquinolone use decreased from 54 to 5 defined daily doses per 1000 patients per day …
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