作者
Jean B Nachega, Jean-Jacques Parienti, Olalekan A Uthman, Robert Gross, David W Dowdy, Paul E Sax, Joel E Gallant, Michael J Mugavero, Edward J Mills, Thomas P Giordano
发表日期
2014/5/1
期刊
Clinical infectious diseases
卷号
58
期号
9
页码范围
1297-1307
出版商
Oxford University Press
简介
Background. Contemporary antiretroviral treatment regimens are simpler than in the past, with lower pill burden and once-daily dosing frequency common. We performed a meta-analysis of randomized controlled trials (RCTs) to investigate the impact of pill burden and once-daily vs twice-daily dosing on ART adherence and virological outcomes.
Methods. A literature search of 4 electronic databases through 31 March 2013 was used. RCTs comparing once-daily vs twice-daily ART regimens that also reported on adherence and virological suppression were included. Study design, study population characteristics, intervention, outcome measures, and study quality were extracted. Study quality was rated using the Cochrane risk-of-bias tool.
Results. Nineteen studies met our inclusion criteria (N = 6312 adult patients). Higher pill burden was …
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