作者
DL Kaufman, MG Erlander, M Clare-Salzler, MA Atkinson, NK Maclaren, AJ442846 Tobin
发表日期
1992/1/1
期刊
The Journal of clinical investigation
卷号
89
期号
1
页码范围
283-292
出版商
American Society for Clinical Investigation
简介
Insulin-dependent diabetes mellitus (IDDM) is thought to result from the autoimmune destruction of the insulin-producing beta cells of the pancreas. Years before IDDM symptoms appear, we can detect autoantibodies to one or both forms of glutamate decarboxylase (GAD65 and GAD67), synthesized from their respective cDNAs in a bacterial expression system. Individual IDDM sera show distinctive profiles of epitope recognition, suggesting different humoral immune responses. Although the level of GAD autoantibodies generally decline after IDDM onset, patients with IDDM-associated neuropathies have high levels of antibodies to GAD, years after the appearance of clinical IDDM. We note a striking sequence similarity between the two GADs and Coxsackievirus, a virus that has been associated with IDDM both in humans and in experimental animals. This similarity suggests that molecular mimicry may play a role …
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DL Kaufman, MG Erlander, M Clare-Salzler… - The Journal of clinical investigation, 1992