作者
Sean P Cullen, Conor M Henry, Conor J Kearney, Susan E Logue, Maria Feoktistova, Graham A Tynan, Ed C Lavelle, Martin Leverkus, Seamus J Martin
发表日期
2013/3/28
期刊
Molecular cell
卷号
49
期号
6
页码范围
1034-1048
出版商
Elsevier
简介
Apoptosis is commonly thought to represent an immunologically silent or even anti-inflammatory mode of cell death, resulting in cell clearance in the absence of explicit activation of the immune system. However, here we show that Fas/CD95-induced apoptosis is associated with the production of an array of cytokines and chemokines, including IL-6, IL-8, CXCL1, MCP-1, and GMCSF. Fas-induced production of MCP-1 and IL-8 promoted chemotaxis of phagocytes toward apoptotic cells, suggesting that these factors serve as "find-me" signals in this context. We also show that RIPK1 and IAPs are required for optimal production of cytokines and chemokines in response to Fas receptor stimulation. Consequently, a synthetic IAP antagonist potently suppressed Fas-dependent expression of multiple proinflammatory mediators and inhibited Fas-induced chemotaxis. Thus, in addition to provoking apoptosis, Fas receptor …
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SP Cullen, CM Henry, CJ Kearney, SE Logue… - Molecular cell, 2013